A study published in Nature Metabolism reveals neural circuits in the mouse brain that promote hunger-driven feeding and suppress pleasure-driven eating. The findings open new possibilities for developing strategies to combat obesity.
“Ideal feeding habits would balance eating for necessity and for pleasure, minimizing the latter,” said co-corresponding author Dr. Yong Xu, professor of pediatrics – nutrition and associate director for basic sciences at the USDA/ARS Children’s Nutrition Research Center at Baylor College of Medicine. “In this study we identified a group of neurons that regulates balanced feeding in the brain.”
Previous studies have highlighted the role of neurons identified by the GABAergic proenkephalin (Penk) marker, an endogenous opioid hormone, on feeding and body weight balance. However, their contribution to regulating hunger- and pleasure-driven feeding had not been elucidated.
In this study, Xu and his colleagues showed that activation of Penk neurons in the brain region called diagonal band of Broca (DBB) of male mice supports an ideal feeding pattern, increasing hunger-driven feeding while reducing pleasure-driven eating.
“I was surprised by this finding,” Xu said. “We and other groups had previously shown that certain groups of neurons affect both feeding types in the same way – they either increase or decrease both types. Here we found that activating DBB-Penk neurons has opposite effects in the two types of feeding; they increase hunger-driven feeding while decreasing eating for pleasure.”
The researchers investigated the mechanism mediating these opposite effects. They discovered that DBB-Penk neurons project into two different brain areas: one regulates hunger-driven feeding and the other controls pleasure-driven eating.
“A subset of DBB-Penk neurons that projects to the paraventricular nucleus of the hypothalamus is preferentially activated upon food presentation during fasting periods, facilitating hunger-driven feeding,” Xu said. “On the other hand, a separate subset of DBB-Penk neurons that projects to a different brain region, the lateral hypothalamus, is preferentially activated when detecting high-fat, high-sugar (HFHS) foods and inhibits their consumption. This is the first study to show a neural circuit that is activated by a reward, HFHS but leads to terminating instead of continuing the pleasurable activity.”
Strikingly, mice in which the entire DBB-Penk population had been eliminated reduced consumption of chow but increased intake of HFHS diet when given free choice between chow and HFHS diets. This resulted in accelerated development of obesity and metabolic disturbances.
“Our findings indicate that the development of obesity is associated with impaired function of some of these brain circuits in mice,” Xu said. “We are interested in further investigating molecular markers within these circuits that could be suitable targets for treatment of human diseases such as obesity.”
Other contributors to this work include Hailan Liu, Yongxiang Li, Meng Yu, Olivia Z. Ginnard, Kristine M. Conde, Mengjie Wang, Xing Fang, Hesong Liu, Longlong Tu, Na Yin, Jonathan C. Bean, Junying Han, Yongjie Yang, Qingchun Tong, Benjamin R. Arenkiel , Chunmei Wang and co-corresponding author Yang He at Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital . The authors are affiliated with one or more institutions including Baylor College of Medicine , Baylor’s USDA/ARS Children’s Nutrition Research Center , Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital , University Of Texas Health Science Center At Houston .
This study was supported by grants from USDA/CRIS (51000-064-01S , 3092-51000-062-04(B)S), Texas Children’s Research Scholar funds , American Heart Association (23POST1030352), NIH NIDDK (1F32DK134121-01A1).
