John J. Warner, MD Chief Executive Officer at Ohio State Health & Discovery | Official website
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Patient Daily | Jun 26, 2026

Experts discuss how depression affects older adults and treatment challenges

The prevalence of depression worldwide continues to grow, with nearly 90% of people diagnosed with depression reporting interference with home, work or social activity, according to a June 26 article from Ohio State Health and Discovery.

Depression is described as highly recurrent. "If you have an episode of depression, there’s a 40% to 60% chance of having another episode. If you have two episodes of depression, the chance of recurrence is 60%. With three episodes, the risk of more is as high as 90%." The article also notes that only 22% of those seeking treatment actually see a specialist, which contributes to significant public health costs in healthcare and disability.

While the typical age for onset is around 30 years old, depression remains one of the most common psychiatric disorders among older adults. As the geriatric population increases, late-life depression will require more attention. Older adults may be especially vulnerable due to major life stressors such as losing loved ones or declining health that limits social engagement. "As their social circle starts to shrink, so does their support system. As a result, the impact of depression on this population can be even greater, as they may be less likely – or less able – to seek help," according to Ohio State Health and Discovery.

The article states that while there is a lower reported prevalence (approximately nine percent) among those aged sixty or older compared to younger adults, this could be influenced by early mortality in vulnerable populations or reluctance to admit psychiatric problems. Despite being less common in older age groups than in younger ones, late-life mood disorders can lead to severe consequences including increased healthcare costs and higher rates of suicide completion among older adults.

Symptoms listed include persistent sadness; loss of interest; changes in appetite or sleep; trouble concentrating; fatigue; restlessness or slowed movement; feelings of worthlessness; inappropriate guilt; and thoughts about death or suicide. Causes are noted as genetic, environmental, psychological and biochemical factors. There is no evidence that causes change significantly with age except for specific conditions like vascular depression or affective syndrome associated with Alzheimer’s disease.

The article emphasizes early diagnosis and appropriate treatment for late-life depression while ruling out other medical explanations such as mild cognitive decline: "Treating late-life depression can offset the impact. In one study, older adults who responded to treatment lived an average of five years longer and had reduced healthcare costs." The Depression Recovery Center at Ohio State offers comprehensive assessments for understanding complex factors contributing to depressive symptoms in older adults.

Ohio State Health and Discovery addresses societal issues such as health equity and substance use through its academic medical center—which includes hospitals and outpatient facilities—and advances health locally and globally through research innovation, education initiatives focused on patient care improvement across communities worldwide, according to its official website.

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