New research presented at the 2025 Annual Scientific Meeting of the American College of Allergy, Asthma and Immunology (ACAAI) shows that a peanut patch treatment, known as epicutaneous immunotherapy, continues to help toddlers with peanut allergies build tolerance over a period of three years.
The Viaskin Peanut Patch delivers small amounts of peanut protein through the skin. The goal is to train the immune system to tolerate peanuts and reduce the risk of severe allergic reactions from accidental exposure. The latest analysis focused on toddlers who initially received a placebo in an earlier one-year study before using the peanut patch for up to three years.
After three years, more than 70% of these children could tolerate an amount equal to at least three to four peanut kernels. Nearly half were able to handle even larger quantities. No cases of treatment-related anaphylaxis were reported during the third year, and skin irritation—identified as the most common side effect—became less frequent over time. Additionally, food challenge reactions became milder after three years compared to after one year.
“These results show that ongoing treatment with the peanut patch continues to improve tolerance and remains safe over time,” said allergist Matthew Greenhawt, MD, MBA, lead author and ACAAI member. “For parents of toddlers with peanut allergies, this kind of approach may one day offer peace of mind by reducing the risk of having an allergic reaction, including severe reactions, from accidental exposure.”
Peanut allergy affects about 2% of children in the United States and is among the main causes of severe allergic reactions. The findings add evidence that early intervention in young children could change how peanut allergy develops. Researchers advise parents not to attempt any form of desensitization at home but instead discuss emerging options with a board-certified allergist.
The ACAAI represents more than 6,000 allergists-immunologists and allied health professionals across the country. It provides resources for patients seeking information or diagnosis related to food allergies on its website AllergyandAsthmaRelief.org.
For additional news from this year's ACAAI meeting or further details about food allergy treatments and finding local specialists, visit AllergyandAsthmaRelief.org or follow #ACAAI25 on social media platforms.
